GSK Augmentin (Synulox/ clavamox) palatable drops 30ml oral suspension (Amoxicillin & Potassium Clav)
AUGMENTIN formulations are indicated for the treatment of infections caused by amoxicillin-resistant organisms producing β-lactamases sensitive to clavulanic acid:
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Upper respiratory tract infections, such as sinusitis, otitis media, recurrent tonsillitis.
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Lower respiratory tract infections, such as acute exacerbations of chronic bronchitis
(caused by amoxicillin-resistant β-lactamase producing Escherichia coli,
Haemophilus influenzae and Haemophilus parainfluenzae), bronchopneumonia.
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Genito-urinary tract infections, such as cystitis, urethritis, pyelonephritis.
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Skin and soft tissue infections, bone infections, wound infections, infections in the mouth.
- Amoxiclav is considered a broad spectrum antibiotic and is not meant to treat viral or parasitic infections.
Side Effects:
- Some animals may vomit shortly after administration of amoxicillin + clavulanate. This may occur in as many as 10 % of dogs. You may try administering with food or full stomach.If vomiting after administration continues to occur, contact your veterinarian.
- It is common for animals to develop diarrhea or loose stools from oral amoxicillin + clavunate.This is caused by a change in the bacterial population in the animal’s intestine.
- Amoxicillin + clavulanate may interact with other medications. Consult your vet if other meds are being given
AUGMENTIN formulations will also be effective in the treatment of infections caused by amoxicillin-sensitive organisms at the appropriate amoxicillin dosage since in this situation the clavulanic acid component does not contribute to the therapeutic effect.
The two components of AUGMENTIN, amoxicillin and clavulanic acid are fully dissociated in aqueous solution at physiological pH. The combination of the 2 molecules act synergistically to breakdown the wall of the bacteria. Both components are rapidly and well absorbed by the oral route of administration. Absorption of AUGMENTIN is optimized when taken at the start of a meal. Amoxicillin serum concentrations achieved with the AUGMENTIN combination are similar to those produced by the oral administration of equivalent doses of amoxicillin alone.
Amoxicillin and clavulanic acid diffuse readily into most body tissues and fluids with the exception of the brain and spinal fluid. Neither amoxicillin nor clavulanic acid is highly protein bound. Clavulanate is an inhibitor of an enzyme produced by bacteria. This enzyme, beta-lactamase, would ordinarily render amoxicillin inactive. Clavulanate has no antibacterial effects; it simply acts as an inhibitor of an important resistance mechanism.
The major route of elimination for amoxicillin is the kidneys, whereas for clavulanic acid it is by both renal and non-renal mechanisms. Approximately 60-70 % of amoxicillin and 40-65 % clavulanic acid is excreted unchanged in urine during the first 6 hours after administration.
Amoxicillin is also partly excreted in the urine as the inactive metabolite (penicilloic acid) in quantities equivalent to 10-25 % of the initial dose. Clavulanic acid is extensively metabolised in man and the metabolites are eliminated in urine and faeces and as CO2in expired air.
Co-administration of probenecid has little effect on the excretion of the clavulanic acid component of the formulation, but delays amoxicillin excretion.
The mean AUC values for amoxicillin are essentially the same following twice-a-day dosing or three-times-a-day dosing. No differences between the b.i.d and t.i.d
Dosing regimes are seen when comparing the amoxicillin T1/2, or Cmax after normalisation for the different doses of amoxicillin administered. Similarly, no differences are seen for the clavulanate T1/2, Cmax or AUC values after appropriate dose normalisation.
DOSAGE: The dose of amoxicillin ranges from 10 to 25 mg/kg (5 to 12 mg per pound) two or three times a day orally. The most common dose of Clavamox® used in dogs and cats is 6.875 mg per pound (13.75 mg/kg) every 12 hours.
